Tesofensine
Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) originally developed for Alzheimer's and Parkinson's disease. During clinical trials, researchers discovered it produced dramatic weight loss — up to twice the effect of existing weight loss drugs. It works by increasing levels of all three major monoamine neurotransmitters, reducing appetite, increasing metabolic rate, and improving satiety signaling. Tesofensine is taken orally and has become a popular compound in peptide/weight loss clinics.
Frequency
Once daily, or 1-2 tablets daily
Cycle Length
8-12 weeks on, 4 weeks off. Can be used longer under medical supervision.
Route
Oral
Research Level
Emerging
Goals
Dosing Protocol
250 mcg to 1 mg orally, daily. Available as 500 mcg capsules (30 ct) or 500 mcg tablets (30 ct). Start low and titrate up based on tolerance. Fasted upon waking or on empty stomach 30 minutes before eating.
Timing
Fasted upon waking, or on empty stomach 30 minutes before eating. Avoid evening dosing due to stimulant effects.
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Potential Side Effects
- Dry mouth
- Insomnia
- Elevated heart rate
- Constipation
- Headache
- Mood changes
Important Warnings
- Stimulant properties — may increase heart rate and blood pressure
- Do not combine with MAOIs or other serotonergic drugs
- Screen for cardiovascular risk factors before use
- Not FDA-approved
Works Well With
Research References
- Astrup A, et al. Lancet. 2008;372(9653):1906-1913. doi:10.1016/S0140-6736(08)61525-1
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Tesofensine may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.