Humanin
Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It is one of the most significant peptides in longevity research due to its powerful cytoprotective effects. Humanin inhibits apoptosis triggered by various stressors, protects neurons from amyloid-beta toxicity (relevant to Alzheimer's), improves insulin sensitivity, and has anti-inflammatory effects. Its levels decline with age, correlating with age-related disease onset.
Frequency
Once daily
Cycle Length
4-8 weeks. Limited long-term human data.
Route
Subcutaneous
Research Level
Emerging
Goals
Dosing Protocol
1-5 mg daily, subcutaneous injection. With standard reconstitution (5 mg in 2 mL), 1 mg = 40 units and 5 mg = 100 units (full syringe) on a U-100 insulin syringe.
Reconstitution
Add 2 mL bacteriostatic water to a 5 mg vial.
Timing
Morning, on an empty stomach.
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Potential Side Effects
- Very few reported
- Mild injection site discomfort
- Theoretical hypoglycemia risk
Important Warnings
- Limited human clinical data
- Monitor blood glucose — may affect insulin sensitivity
Research References
- Hashimoto Y, et al. Proc Natl Acad Sci USA. 2001;98(11):6336-6341. doi:10.1073/pnas.101133498
- Lee C, et al. Cell Metab. 2015;21(3):443-454. doi:10.1016/j.cmet.2015.02.004
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Humanin may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.