Ipamorelin
Ipamorelin is a highly selective growth hormone secretagogue that stimulates the pituitary via the ghrelin receptor without significantly affecting cortisol, prolactin, or appetite. This makes it the cleanest GH peptide available and ideal for beginners or those sensitive to side effects. It produces reliable, dose-dependent GH pulses and is commonly stacked with CJC-1295 for enhanced results. Benefits include improved sleep, fat loss, lean muscle gains, and better skin quality.
Frequency
Up to 3x daily — 5 days on, 2 days off per week
Cycle Length
8-12 weeks on, 4 weeks off
Route
Subcutaneous
Research Level
Established
Goals
Dosing Protocol
200-300 mcg per injection (4-6 units), up to 3 times a day. With standard reconstitution (10 mg in 2 mL), 0.05 mg per unit — 4 units = 200 mcg, 6 units = 300 mcg on a U-100 insulin syringe. 5 days on, 2 days off.
Reconstitution
Add 2 mL bacteriostatic water to a 10 mg vial.
Timing
Fasted — 30 minutes before each meal, up to 3 times a day.
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Potential Side Effects
- Mild head rush (rare)
- Slight water retention
- Generally very well tolerated
Important Warnings
- Do not use with active cancer
- WADA-prohibited substance
Frequently Asked Questions
What is Ipamorelin used for?
Ipamorelin is used to stimulate growth hormone release for goals like better sleep, recovery, fat loss, and lean-mass support. It is often chosen by people who want a cleaner GH secretagogue profile.
How often can Ipamorelin be used?
Ipamorelin is commonly used up to three times per day on a 5-days-on, 2-days-off schedule. Many people use fewer injections depending on whether the focus is sleep, recovery, or body composition.
Does Ipamorelin increase appetite or cortisol?
Ipamorelin is usually selected because it is more selective than older GHRPs and is less associated with appetite, cortisol, and prolactin issues. That cleaner profile is one of its main selling points.
Is Ipamorelin commonly stacked with CJC-1295?
Yes. Ipamorelin is very commonly stacked with CJC-1295 because the combination supports stronger GH signaling than either compound alone and is widely used in sleep and recomposition protocols.
Research References
- Raun K, et al. Eur J Endocrinol. 1998;139(5):552-561. doi:10.1530/eje.0.1390552
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Related Peptides
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Ipamorelin may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.