Dihexa
Dihexa is a synthetic hexapeptide analog of angiotensin IV that is roughly 10 million times more potent than BDNF at forming new neural connections. It works by activating the hepatocyte growth factor (HGF)/MET receptor system, which plays a crucial role in synaptogenesis and neuronal repair. Originally developed for Alzheimer's research, Dihexa shows remarkable potential for memory enhancement and cognitive repair.
Frequency
1-3 times daily
Cycle Length
4-8 weeks. Limited long-term safety data — cycle conservatively.
Route
Oral
Research Level
Experimental
Goals
Dosing Protocol
10-30 mg daily, taken orally (8-30 mg tablets available). Take 1-3 tablets split throughout the day. On empty stomach 30 minutes before eating.
Timing
On empty stomach 30 minutes before eating. Do not combine with other potent nootropics initially.
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Potential Side Effects
- Limited human safety data
- Potential overstimulation
- Blood pressure changes
- Use with caution
Important Warnings
- No human clinical trials — all data is preclinical
- HGF/MET pathway activation may theoretically promote tumor growth
- Not for use by individuals with cancer or cancer history
Works Well With
Research References
- McCoy AT, et al. J Pharmacol Exp Ther. 2013;344(1):141-154. doi:10.1124/jpet.112.199497
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Dihexa may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.