GHK-Cu
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide with a bound copper ion. It declines significantly with age and is considered one of the most important anti-aging peptides. GHK-Cu stimulates collagen and elastin production, promotes wound healing, reduces inflammation, supports hair growth by increasing follicle size, and has demonstrated anti-cancer properties. Available as injectable, topical cream, and serum forms.
Frequency
Daily (injectable), 30 days on / 14 days off
Cycle Length
30 days on, 14 days off. Topical can be used continuously.
Route
Topical
Research Level
Established
Goals
Dosing Protocol
Injectable: 1-2 mg daily (4-8 units for 50 mg vial, 3-5 units for 75 mg vial, 3-6 units for 100 mg vial). For 50 mg vial reconstituted with 2 mL, 0.25 mg per unit. For 75 mg vial reconstituted with 2 mL, 0.375 mg per unit. For 100 mg vial reconstituted with 3 mL, 0.33 mg per unit. 30 days on, 14 days off. Topical: apply serum/cream directly to skin 1-2x daily.
Reconstitution
Add 2 mL bacteriostatic water to a 50 mg or 75 mg vial. Add 3 mL to a 100 mg vial.
Timing
Injectable: evening. Topical: after cleansing, morning and/or evening.
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Potential Side Effects
- Injection site redness
- Mild stomach discomfort (injectable)
- Skin irritation (topical, rare)
Important Warnings
- Do not use if you have Wilson's disease (copper accumulation disorder)
- Topical forms are cosmetic supplements — injectable is research-grade
Works Well With
Research References
- Pickart L, et al. BioMed Res Int. 2015;2015:648108. doi:10.1155/2015/648108
- Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. GHK-Cu may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.